{"product_id":"original-synbiotic-formula","title":"Original Synbiotic","description":"\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eThe Original Synbiotic Formula is the gold standard of probiotic formulas. Five pedigree ATCC probiotic lactic acid bacteria are grown for hardiness and stability. The Original is a powerfully elegant mix of prebiotic and probiotic.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eAdd one teaspoon to your daily routine.\u003c\/p\u003e\n\u003ch6\u003eDescription \u003c\/h6\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e20 billion cfu\/tsp of certified strains of pedigreed probiotic with Therapeutic Foods in a synbiotic formula of L. acidophilus, B. longum, L. rhamnosus, L. plantarum, S. thermophilus and 4 grams of inulin derived from organic chicory fiber. Advanced freeze-drying technology. 120 grams\/bottle. 4 grams\/ tsp. Dairy free.  Soy free. Gluten free. No excipients.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eMicrobiome Technology creates hardy and viable pedigreed strains of \u003cem\u003eL. acidophilus, B. longum, L. rhamnosus, L. plantarum, S. thermophilus\u003c\/em\u003e.\u003c\/li\u003e\n\u003cli\u003eOriginal strains of lactic acid bacteria are based on ATCC prototypical strains and confirmed routinely by 16sRNA sequencing to provide highest quality probiotic material.\u003c\/li\u003e\n\u003cli\u003eThe Original Strains are chosen for their strength, compatibility, safety and their 40 years of proven ability to neutralize food borne pathogens and xenobiotics.\n\u003cul\u003e\n\u003cli\u003eStrains selected to protect, counteract and neutralize dietary toxins, mutagens, carcinogens and infectious organisms.\u003c\/li\u003e\n\u003cli\u003eThe contamination of food with aflatoxins is a worldwide problem. Mold mycotoxins compromise the blood-brain barrier and induce neurodegenerative processes. \u003cem\u003eL rhamnosus\u003c\/em\u003e binds AFB1 in vivo and reduces bio-absorption of the toxin from the gut. \u003cem\u003eL. acidophilus\u003c\/em\u003e and \u003cem\u003eB. longum\u003c\/em\u003e neutralize AFB1 and AFM1 by binding mechanisms. \u003cem\u003eS. thermophilus\u003c\/em\u003e reduces content of ochratoxin A.\u003c\/li\u003e\n\u003cli\u003eMutagens cause impaired cell function, cell death or cell transformation into cancer cells. \u003cem\u003eL. acidophilus, B. longum, L. rhamnosus, S. thermophilus\u003c\/em\u003e and \u003cem\u003eL. plantarum\u003c\/em\u003e neutralize heterocyclic amines and nitrosamines, two of the most common and powerful mutagenic molecules found in our diet.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003eOur home is a global environment. Infectious organisms come from all corners of the world.\n\u003cul\u003e\n\u003cli\u003eVerocytotoxin producing E. coli s0157 are emerging food borne pathogens worldwide. \u003cem\u003eB. longum\u003c\/em\u003eneutralizes this toxin.\u003c\/li\u003e\n\u003cli\u003eThe collective ability of the Original probiotic organisms to protect the frontline border of our GI tract membrane from the aggressive enterovirulent pathogens is accomplished via: the production of bactercins, creation of an acid barrier, stimulation of the cell mediated immune system and protective colonization of enterocytes.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003eThe lactic acid bacterial strains in the Original Synbiotic Formula have demonstrated the ability to inhibit the formation of precancerous colon lesions. Numerous trials performed validate findings.\u003c\/li\u003e\n\u003cli\u003ePure inulin, derived from chicory fiber, provides support as a Therapeutic Foods carrier and prebiotic. Provides an ideal food source for the lactic acid organisms to grow, thrive and to protect.\u003c\/li\u003e\n\u003cli\u003eIn the process of fermentation, inulin produces butyric acid and therefore:\n\u003cul\u003e\n\u003cli\u003eCorrects GI permeability- establishes tight junctions.\u003c\/li\u003e\n\u003cli\u003eInhibits colon cancer: stimulating the differentiation of stem cells.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003eImproves habit of bowel regularity\u003c\/li\u003e\n\u003cli\u003eNo fillers, flowing agents or excipients of any kind.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch6\u003eIngredients\u003cbr\u003e\n\u003c\/h6\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e1 Teaspoon Contains: \u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eCalories 5 \u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eTotal Carbohydrate 3g \u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eDietary fiber 3g \u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eSoluble fiber 3g \u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eProprietary Probiotic Blend 20billion CFU    3.38g \u003c\/span\u003e\u003cbr\u003e\u003cem\u003e  L. acidophilus \u003cbr\u003e  L. casei rhamnosus \u003cbr\u003e  L. plantarum \u003cbr\u003e  S. thermophilus \u003cbr\u003e  B. longum \u003cbr\u003e\u003c\/em\u003e\u003cspan\u003eInulin (from organic chicory root)\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eContainer:  120 grams\u003c\/span\u003e\u003c\/p\u003e\n\u003ch6\u003e\u003cspan mce-data-marked=\"1\"\u003eResearch\u003c\/span\u003e\u003c\/h6\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003e\u003cb\u003e\u003ci\u003eImmune Support\u003c\/i\u003e\u003c\/b\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eAFRC, R. F. (1989). Probiotics in man and animals. \u003ci\u003eJournal of applied bacteriology\u003c\/i\u003e, \u003ci\u003e66\u003c\/i\u003e(5), 365-378. \u003ca href=\"https:\/\/doi.org\/10.1111\/j.1365-2672.1989.tb05105.x\"\u003e\u003cspan class=\"s2\"\u003ehttps:\/\/doi.org\/10.1111\/j.1365-2672.1989.tb05105.x\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eAguilar, C., Mano, M., \u0026amp; Eulalio, A. (2018). MicroRNAs at the Host–Bacteria Interface: Host Defense or Bacterial Offense. \u003ci\u003eTrends in microbiology\u003c\/i\u003e. \u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0966842X18302348\"\u003e\u003cspan class=\"s2\"\u003eAbstract\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eAzcarate-Peril, M.A., Sikes, M., Bruno-Barcena, J.M. (2011). The intestinal microbiota, gastrointestinal environment and colorectal cancer: a putative role for probiotics in prevention of colorectal cancer? \u003ci\u003eAm J Physiol Gastrointest Liver Physiol\u003c\/i\u003e, \u003ci\u003e301\u003c\/i\u003e, G401-G424. doi:10.1152\/ajpgi.00110.2011.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eBocci V. (1992). The neglected organ: Bacterial flora has a crucial immunostimulatory role. \u003ci\u003ePerspectives in Biology and Medince\u003c\/i\u003e, \u003ci\u003e35\u003c\/i\u003e(2), 251–260. \u003ca href=\"https:\/\/muse.jhu.edu\/article\/402661\/summary\"\u003e\u003cspan class=\"s2\"\u003eAbstract\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eCianci, R., Franza, L., Schinzari, G., Rossi, E., Ianiro, G., Tortora, G., ... \u0026amp; Cammarota, G. (2019). 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M., Cazorla, S. I., Dumit, J. M. L., Vélez, E., \u0026amp; Perdigón, G. (2019). Beneficial Effects of Probiotic Consumption on the Immune System. \u003ci\u003eAnnals of Nutrition and Metabolism\u003c\/i\u003e, \u003ci\u003e74\u003c\/i\u003e(2), 115-124. \u003ca href=\"https:\/\/www.karger.com\/Article\/Abstract\/496426\"\u003e\u003cspan class=\"s2\"\u003eAbstract\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eGern, J.E. (2015). Promising candidates for allergy prevention. \u003ci\u003eJournal of Allergy and Clinical Immunology, 136\u003c\/i\u003e (1), 23–28. \u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0091674915007216\"\u003e\u003cspan class=\"s2\"\u003eAbstract\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eHarata, G., He, F., Takahashi, K., Hosono, A., Miyazawa, K., Yoda, K., ... \u0026amp; Kaminogawa, S. 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A cellular microRNA mediates antiviral defense in human cells. \u003ci\u003eScience\u003c\/i\u003e, \u003ci\u003e308\u003c\/i\u003e(5721), 557-560. \u003ca href=\"https:\/\/www.researchgate.net\/publication\/7891502_A_Cellular_MicroRNA_Mediates_Antiviral_Defense_in_Human_Cells\"\u003e\u003cspan class=\"s2\"\u003eArticle\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eLilly, D. M., \u0026amp; Stillwell, R. H. (1965). Probiotics: growth-promoting factors produced by microorganisms. \u003ci\u003eScience\u003c\/i\u003e, \u003ci\u003e147\u003c\/i\u003e(3659), 747-748. \u003ca href=\"https:\/\/doi.org\/10.1126\/science.147.3659.747\"\u003e\u003cspan class=\"s2\"\u003ehttps:\/\/doi.org\/10.1126\/science.147.3659.747\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eMa, F., Xu, S., Liu, X., Zhang, Q., Xu, X., Liu, M., ... \u0026amp; Cao, X. (2011). The microRNA miR-29 controls innate and adaptive immune responses to intracellular bacterial infection by targeting interferon-γ. \u003ci\u003eNature immunology\u003c\/i\u003e, \u003ci\u003e12\u003c\/i\u003e(9), 861. \u003ca href=\"https:\/\/www.nature.com\/articles\/ni.2073\"\u003e\u003cspan class=\"s2\"\u003eAbstract\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eMadsen, K. (2006). Probiotics and the immune response. \u003ci\u003eJ Clin Gastroenterol\u003c\/i\u003e, \u003ci\u003e40\u003c\/i\u003e, 232–4. \u003ca href=\"https:\/\/journals.lww.com\/jcge\/Abstract\/2006\/03000\/Probiotics_and_the_Immune_Response.14.aspx\"\u003e\u003cspan class=\"s2\"\u003eAbstract\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eMarshall, W.E. (2014). Bacterial ORNs, a new paradigm to prevent infection. In Weston A. Price Foundation, online \u003ca href=\"https:\/\/www.westonaprice.org\/health-topics\/farm-ranch\/bacterial-orns-a-new-paradigm-to-prevent-infections\/\"\u003e\u003cspan class=\"s2\"\u003eArticle.\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eMarshall, W. E. (2010). Oligoribonucleotides alert the immune system of animals to the imminence of microbial infection. \u003ci\u003eU.S. Patent No. 7,678,557\u003c\/i\u003e. Washington, DC: U.S. Patent and Trademark Office. \u003ca href=\"https:\/\/patents.google.com\/patent\/US7189834B2\/en\"\u003e\u003cspan class=\"s2\"\u003eArticle\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eNakata, K., Sugi, Y., Narabayashi, H., Kobayakawa, T., Nakanishi, Y., Tsuda, M., ... \u0026amp; Takahashi, K. (2017). Commensal microbiota-induced microRNA modulates intestinal epithelial permeability through the small GTPase ARF4. \u003ci\u003eJournal of Biological Chemistry\u003c\/i\u003e, \u003ci\u003e292\u003c\/i\u003e(37), 15426-15433. \u003ca href=\"http:\/\/www.jbc.org\/content\/292\/37\/15426.short\"\u003e\u003cspan class=\"s2\"\u003eAbstract\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eNishiyama, K., Sugiyama, M., \u0026amp; Mukai, T. (2016). Adhesion properties of lactic acid bacteria on intestinal mucin. \u003ci\u003eMicroorganisms\u003c\/i\u003e, \u003ci\u003e4\u003c\/i\u003e(3), 34. \u003ca href=\"https:\/\/www.mdpi.com\/2076-2607\/4\/3\/34\"\u003e\u003cspan class=\"s2\"\u003eAbstract\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eParker, R. B. (1974). Probiotics, the other half of the antibiotic story. \u003ci\u003eAnim Nutr Health\u003c\/i\u003e, \u003ci\u003e29\u003c\/i\u003e, 4-8.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eParvez, S., Malik, K.A., Kang, S., \u0026amp; Kim, H.Y. (2006). Probiotics and their fermented food products are beneficial for health. J Appl Microbiol. \u003ci\u003e100\u003c\/i\u003e, 1171–85. \u003ca href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1111\/j.1365-2672.2006.02963.x\"\u003e\u003cspan class=\"s2\"\u003eArticle\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eRoberfroid, M.B. (2000). Prebiotics and probiotics: Are they functional foods? Am J Clin Nutr, \u003ci\u003e71\u003c\/i\u003e, 1682S–7S. \u003ca href=\"https:\/\/academic.oup.com\/ajcn\/article\/71\/6\/1682S\/4729644\"\u003e\u003cspan class=\"s2\"\u003eArticle\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eSaini, R., Saini, S., Sugandha. (2009). Probiotics: The health boosters. J Cutan Aesthet Surg, \u003ci\u003e2\u003c\/i\u003e, 112. \u003ca href=\"http:\/\/www.jcasonline.com\/article.asp?issn=0974-2077;year=2009;volume=2;issue=2;spage=112;epage=112;aulast=Saini\"\u003e\u003cspan class=\"s2\"\u003eLetter\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eSalas-Jara, M. J., Ilabaca, A., Vega, M., \u0026amp; García, A. (2016). Biofilm forming Lactobacillus: new challenges for the development of probiotics. \u003ci\u003eMicroorganisms\u003c\/i\u003e, \u003ci\u003e4\u003c\/i\u003e(3), 35. doi:\u003ca href=\"http:\/\/dx.doi.org\/10.3390\/microorganisms4030035\"\u003e\u003cspan class=\"s2\"\u003e10.3390\/microorganisms403003\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eShmaryahu, A., Carrasco, M., \u0026amp; Valenzuela, P. D. (2014). Prediction of bacterial microRNAs and possible targets in human cell transcriptome. \u003ci\u003eJournal of Microbiology\u003c\/i\u003e, \u003ci\u003e52\u003c\/i\u003e(6), 482-489. \u003ca href=\"https:\/\/link.springer.com\/article\/10.1007\/s12275-014-3658-3\"\u003e\u003cspan class=\"s2\"\u003eAbstract\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eStaedel, C., \u0026amp; Darfeuille, F. (2013). Micro RNA s and bacterial infection. \u003ci\u003eCellular microbiology\u003c\/i\u003e, \u003ci\u003e15\u003c\/i\u003e(9), 1496-1507. \u003ca href=\"https:\/\/doi.org\/10.1111\/cmi.12159\"\u003e\u003cspan class=\"s2\"\u003eAbstract\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eSunkavalli, U., Aguilar, C., Silva, R. J., Sharan, M., Cruz, A. R., Tawk, C., ... \u0026amp; Eulalio, A. (2017). Analysis of host microRNA function uncovers a role for miR-29b-2-5p in Shigella capture by filopodia. \u003ci\u003ePLoS pathogens\u003c\/i\u003e, \u003ci\u003e13\u003c\/i\u003e(4), e1006327. \u003ca href=\"https:\/\/journals.plos.org\/plospathogens\/article?rev=2\u0026amp;id=10.1371\/journal.ppat.1006327\"\u003e\u003cspan class=\"s2\"\u003eAbstract\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eWahid, F., Shehzad, A., Khan, T., \u0026amp; Kim, Y. Y. (2010). MicroRNAs: synthesis, mechanism, function, and recent clinical trials. \u003ci\u003eBiochimica et Biophysica Acta (BBA)-Molecular Cell Research\u003c\/i\u003e, \u003ci\u003e1803\u003c\/i\u003e(11), 1231-1243.  \u003ca href=\"https:\/\/doi.org\/10.1016\/j.bbamcr.2010.06.013\"\u003e\u003cspan class=\"s2\"\u003ehttps:\/\/doi.org\/10.1016\/j.bbamcr.2010.06.01\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eZhao, Y., \u0026amp; Lukiw, W. J. (2018). 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Beneficial effects of probiotics, prebiotics, synbiotics, and psychobiotics in inflammatory bowel disease. \u003ci\u003eInflammatory bowel diseases\u003c\/i\u003e, \u003ci\u003e21\u003c\/i\u003e(7), 1674-1682. \u003ca href=\"https:\/\/academic.oup.com\/ibdjournal\/article-abstract\/21\/7\/1674\/4604272\"\u003e\u003cspan class=\"s2\"\u003eAbstract\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eZhang, Y., Li, L., Guo, C., Mu, D., Feng, B., Zuo, X., \u0026amp; Li, Y. (2016). Effects of probiotic type, dose and treatment duration on irritable bowel syndrome diagnosed by Rome III criteria: a meta-analysis. \u003ci\u003eBMC gastroenterology\u003c\/i\u003e, \u003ci\u003e16\u003c\/i\u003e(1), 62. \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27296254\"\u003e\u003cspan class=\"s2\"\u003eAbstract\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003e\u003cb\u003e\u003ci\u003eModulating a Healthy Microbiome: Immunity, Intestinal Barrier \u0026amp; Brain\u003c\/i\u003e\u003c\/b\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eArora, T., \u0026amp; Bäckhed, F. (2016). The gut microbiota and metabolic disease: current understanding and future perspectives. \u003ci\u003eJournal of internal medicine\u003c\/i\u003e, \u003ci\u003e280\u003c\/i\u003e(4), 339-349. \u003ca href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1111\/joim.12508\"\u003e\u003cspan class=\"s2\"\u003eArticle\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eBlackwood, B. P., Yuan, C. Y., Wood, D. R., Nicolas, J. D., Grothaus, J. S., \u0026amp; Hunter, C. J. (2017). 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DOI:\u003ca href=\"https:\/\/doi.org\/10.3945\/an.114.005835\"\u003e\u003cspan class=\"s2\"\u003e10.3945\/an.114.005835\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eEverard, A., \u0026amp; Cani, P. (2013). Diabetes, obesity and gut microbiota. \u003ci\u003eBest Pract. Res. Clin. Gastroenterol\u003c\/i\u003e, \u003ci\u003e27\u003c\/i\u003e, 73–83. \u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1521691813000619?via%253Dihub\"\u003e\u003cspan class=\"s2\"\u003eArticle\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eFalcinelli, S., Rodiles, A., Hatef, A., Picchietti, S., Cossignani, L., Merrifield, D. L., ... \u0026amp; Carnevali, O. (2017). Dietary lipid content reorganizes gut microbiota and probiotic L. rhamnosus attenuates obesity and enhances catabolic hormonal milieu in zebrafish. \u003ci\u003eScientific reports\u003c\/i\u003e, \u003ci\u003e7\u003c\/i\u003e(1), 5512. \u003ca href=\"https:\/\/www.nature.com\/articles\/s41598-017-05147-w\"\u003e\u003cspan class=\"s2\"\u003eArticle\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eFrazier, T. H., DiBaise, J. K., \u0026amp; McClain, C. J. (2011). Gut microbiota, intestinal permeability, obesity-induced inflammation, and liver injury. \u003ci\u003eJournal of Parenteral and Enteral Nutrition\u003c\/i\u003e, \u003ci\u003e35\u003c\/i\u003e(5_suppl), 14S-20S. \u003ca href=\"https:\/\/www.immuron.com.au\/assets\/files\/Gut-microbiome-and-NASH.PDF\"\u003e\u003cspan class=\"s2\"\u003eArticle\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eHan, J. L., \u0026amp; Lin, H. L. (2014). Intestinal microbiota and type 2 diabetes: from mechanism insights to therapeutic perspective. \u003ci\u003eWorld journal of gastroenterology: WJG\u003c\/i\u003e, \u003ci\u003e20\u003c\/i\u003e(47), 17737. \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4273124\/\"\u003e\u003cspan class=\"s2\"\u003eArticle\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eKorkmaz, O. A., Sadi, G., Kocabas, A., Yildirim, O. G., Sumlu, E., Koca, H. B., ... \u0026amp; Bilgehan, M. Lactobacillus helveticus and Lactobacillus plantarum modulate renal antioxidant status in a rat model of fructose-induced metabolic syndrome. \u003ca href=\"https:\/\/www.researchgate.net\/profile\/Goekhan_Sadi\/publication\/331348421_Lactobacillus_helveticus_and_Lactobacillus_plantarum_modulate_renal_antioxidant_status_in_a_rat_model_of_fructose-induced_metabolic_syndrome\/links\/5c7932ba299bf1268d2f7c5d\/Lactobacillus-helveticus-and-Lactobacillus-plantarum-modulate-renal-antioxidant-status-in-a-rat-model-of-fructose-induced-metabolic-syndrome.pdf\"\u003e\u003cspan class=\"s2\"\u003eArticle\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eMacfarlane, S., Cleary, S., Bahrami, B., Reynolds, N., \u0026amp; Macfarlane, G. T. (2013). Synbiotic consumption changes the metabolism and composition of the gut microbiota in older people and modifies inflammatory processes: a randomised, double\u003c\/span\u003e\u003cspan class=\"s4\"\u003e‐\u003c\/span\u003e\u003cspan class=\"s1\"\u003eblind, placebo\u003c\/span\u003e\u003cspan class=\"s4\"\u003e‐\u003c\/span\u003e\u003cspan class=\"s1\"\u003econtrolled crossover study. \u003ci\u003eAlimentary pharmacology \u0026amp; therapeutics\u003c\/i\u003e, \u003ci\u003e38\u003c\/i\u003e(7), 804-816. \u003ca href=\"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.12453\"\u003e\u003cspan class=\"s2\"\u003eArticle\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eMarques, F. Z., Mackay, C. R., \u0026amp; Kaye, D. M. (2018). Beyond gut feelings: how the gut microbiota regulates blood pressure. \u003ci\u003eNature Reviews Cardiology\u003c\/i\u003e, \u003ci\u003e15\u003c\/i\u003e(1), 20. \u003ca href=\"https:\/\/www.nature.com\/articles\/nrcardio.2017.120\"\u003e\u003cspan class=\"s2\"\u003eArticle\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eQin, Y., Roberts, J. D., Grimm, S. A., Lih, F. B., Deterding, L. J., Li, R., ... \u0026amp; Wade, P. A. (2018). An obesity-associated gut microbiome reprograms the intestinal epigenome and leads to altered colonic gene expression. \u003ci\u003eGenome biology\u003c\/i\u003e, \u003ci\u003e19\u003c\/i\u003e(1), 7. \u003ca href=\"https:\/\/genomebiology.biomedcentral.com\/articles\/10.1186\/s13059-018-1389-1\"\u003e\u003cspan class=\"s2\"\u003eArticle\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eRoberfroid, M., Gibson, G. R., Hoyles, L., McCartney, A. L., Rastall, R., Rowland, I., ... \u0026amp; Guarner, F. (2010). Prebiotic effects: metabolic and health benefits. \u003ci\u003eBritish Journal of Nutrition\u003c\/i\u003e, \u003ci\u003e104\u003c\/i\u003e(S2), S1-S63. \u003ca href=\"https:\/\/www.cambridge.org\/core\/journals\/british-journal-of-nutrition\/article\/prebiotic-effects-metabolic-and-health-benefits\/F644C98393E2B3EB64A562854115D368\"\u003e\u003cspan class=\"s2\"\u003eAbstract\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eSerino, M., Blasco-Baque, V., Nicolas, S., \u0026amp; Burcelin, R. (2014). Managing the manager: gut microbes, stem cells and metabolism. \u003ci\u003eDiabetes \u0026amp; metabolism\u003c\/i\u003e, \u003ci\u003e40\u003c\/i\u003e(3), 186-190. \u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1262363613002346\"\u003e\u003cspan class=\"s2\"\u003eAbstract\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eYan Q, Li X, Feng B. (2015). The efficacy and safety of probiotics intervention in preventing conversion of impaired glucose tolerance to diabetes: study protocol for a randomized, double-blinded, placebo controlled trial of the Probiotics Prevention Diabetes Programme (PPDP). \u003ci\u003eBMC Endocr Discord\u003c\/i\u003e; 15(1): 74. \u003ca href=\"https:\/\/bmcendocrdisord.biomedcentral.com\/articles\/10.1186\/s12902-015-0071-9\"\u003e\u003cspan class=\"s2\"\u003eArticle\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003e\u003cb\u003e\u003ci\u003eCardiovascular and Fatty Liver Support\u003c\/i\u003e\u003c\/b\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eÁlvarez-Mercado, A. I., Navarro-Oliveros, M., Robles-Sánchez, C., Plaza-Díaz, J., Sáez-Lara, M. J., Muñoz-Quezada, S., ... \u0026amp; Abadía-Molina, F. (2019). Microbial Population Changes and Their Relationship with Human Health and Disease. \u003ci\u003eMicroorganisms\u003c\/i\u003e, \u003ci\u003e7\u003c\/i\u003e(3), 68. \u003ca href=\"https:\/\/www.mdpi.com\/2076-2607\/7\/3\/68\/htm\"\u003e\u003cspan class=\"s2\"\u003eArticle\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eDelzenne, N. M., Knudsen, C., Beaumont, M., Rodriguez, J., Neyrinck, A. M., \u0026amp; Bindels, L. B. (2019). Contribution of the gut microbiota to the regulation of host metabolism and energy balance: a focus on the gut–liver axis. \u003ci\u003eProceedings of the Nutrition Society\u003c\/i\u003e, 1-10. \u003ca href=\"https:\/\/www.cambridge.org\/core\/journals\/proceedings-of-the-nutrition-society\/article\/contribution-of-the-gut-microbiota-to-the-regulation-of-host-metabolism-and-energy-balance-a-focus-on-the-gutliver-axis\/9C58A0E320AB35547FE219EDF19F9AE6\"\u003e\u003cspan class=\"s2\"\u003eAbstract\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eFernandes, R., do Rosario, V. A., Mocellin, M. C., Kuntz, M. G., \u0026amp; Trindade, E. B. (2017). Effects of inulin-type fructans, galacto-oligosaccharides and related synbiotics on inflammatory markers in adult patients with overweight or obesity: A systematic review. \u003ci\u003eClinical Nutrition\u003c\/i\u003e, \u003ci\u003e36\u003c\/i\u003e(5), 1197-1206. \u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0261561416312754\"\u003e\u003cspan class=\"s2\"\u003eAbstract\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eIacono, A., Raso, G. M., Canani, R. B., Calignano, A., \u0026amp; Meli, R. (2011). Probiotics as an emerging therapeutic strategy to treat NAFLD: focus on molecular and biochemical mechanisms. \u003ci\u003eThe Journal of nutritional biochemistry\u003c\/i\u003e, \u003ci\u003e22\u003c\/i\u003e(8), 699-711. \u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0955286310002408\"\u003e\u003cspan class=\"s2\"\u003eArticle\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eJohnson-Henry et al. (2008). Lactobacillus rhamnosus strain GG prevents enterohemorrhagic Escherichia coli 0157:H7- Induced changes in epithelial barrier function. Infect Immun; 76:1340-1348. \u003ca href=\"https:\/\/iai.asm.org\/content\/76\/4\/1340.short\"\u003e\u003cspan class=\"s2\"\u003eAbstract\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eLee et al. (2006). Human originated bacteria, \u003ci\u003eLactobacillus rhamnosus\u003c\/i\u003e PL60, produce conjugated linoleic acid and show anti-obesity effects in diet-induced obese mice. \u003ci\u003eBiochim Biophys Acta\u003c\/i\u003e; 1761: 736-744. \u003ca href=\"http:\/\/eanimal.snu.ac.kr\/Aboutus\/paper\/papers\/bbalip.pdf\"\u003e\u003cspan class=\"s2\"\u003eArticle\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eSafari, Z., \u0026amp; Gérard, P. (2019). The links between the gut microbiome and non-alcoholic fatty liver disease (NAFLD). \u003ci\u003eCellular and Molecular Life Sciences\u003c\/i\u003e, 1-18. \u003ca href=\"https:\/\/link.springer.com\/article\/10.1007\/s00018-019-03011-w\"\u003e\u003cspan class=\"s2\"\u003eAbstract\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eShalitin, S., Battelino, T., \u0026amp; Moreno, L. A. (2019). Obesity, Metabolic Syndrome and Nutrition. \u003ci\u003eNutrition and Growth: Yearbook 2019\u003c\/i\u003e, \u003ci\u003e119\u003c\/i\u003e, 13-42.  \u003ca href=\"https:\/\/books.google.com\/books?hl=en\u0026amp;lr=\u0026amp;id=Y-OGDwAAQBAJ\u0026amp;oi=fnd\u0026amp;pg=PT23\u0026amp;dq=+meta-analysis+of+the+prebiotics+and+synbiotics+effects+on+glycaemia,+insulin+concentrations+and+lipid+parameters+in+adult+patients+with+overweight+or+obesity.\u0026amp;ots=yJ9bP-ZUDn\u0026amp;sig=GtbpOFXdGAGvm9drVMb4rQHclPc#v=onepage\u0026amp;q\u0026amp;f=false\"\u003e\u003cspan class=\"s2\"\u003eChapter\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eWang et al. (2009). Effects of \u003ci\u003eLactobacillus plantarum\u003c\/i\u003e MA2 isolated from Tibet kefir on lipid metabolism and intestinal microflora of rats fed on high-cholesterol diet. Appl Microbiol Biotechnol; 84: 341-347. \u003ca href=\"https:\/\/link.springer.com\/article\/10.1007\/s00253-009-2012-x\"\u003e\u003cspan class=\"s2\"\u003eAbstract\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eYadav et al. (2007). Antidiabetic effect of probiotic dahl containing \u003ci\u003eLactobacillus acidophilus\u003c\/i\u003e and \u003ci\u003eLactobacillus casei\u003c\/i\u003e in high fructose fed rats. \u003ci\u003eNutrition\u003c\/i\u003e; 23: 62-68. \u003ca href=\"https:\/\/www.researchgate.net\/profile\/Hariom_Yadav2\/publication\/6711708_Antidiabetic_effect_of_probiotic_dahi_containing_Lactobacillus_acidophilus_and_Lactobacillus_casei_in_high_fructose_fed_rats\/links\/5b22d73faca272277faf9632\/Antidiabetic-effect-of-probiotic-dahi-containing-Lactobacillus-acidophilus-and-Lactobacillus-casei-in-high-fructose-fed-rats.pdf\"\u003e\u003cspan class=\"s2\"\u003eArticle\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eYari, Z., \u0026amp; Hekmatdoost, A. (2019). Dietary Interventions in Fatty Liver. In \u003ci\u003eDietary Interventions in Gastrointestinal Diseases\u003c\/i\u003e (pp. 245-255). Academic Press. \u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/B978012814468800020X\"\u003e\u003cspan class=\"s2\"\u003eAbstract\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch6\u003e\n\u003cspan\u003eProtocol\u003c\/span\u003e\u003cbr\u003e\n\u003c\/h6\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eORIGINAL\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003e— The Original is designed as a foundational probiotic formula for the whole family.\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eHard working probiotic\u003c\/i\u003e: The Original is designed to handle and neutralize carcinogens, toxins, molds, yeasts, and food pathogens (e.g., salmonella). The probiotic mix binds heavy metals. Take 1 teaspoon a day. For babies, start with a few grains (mothers can dip their pinkie in the mix to feed the baby). Sensitive individuals start with ¼ teaspoon and gradually up the dosage.* \u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eleaky gut\u003c\/i\u003e: The Original creates a slightly acidic pH level in the GI Tract to protect the gut membrane from pathogens like yeast. The mix produces amazingly high amounts of the short chain fatty acid butyrate, which facilitate the tightening of the gut membrane. Take 1 teaspoon daily (can take 1 teaspoon three times day during acute bouts of gastric distress).*\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eDigestion\u003c\/i\u003e: Take 1 teaspoon to improve digestion, dissolve in mouth slowly. The Original in fact helps the digestion of polyphenols from fruits, berries, veggies, and greens into bioavailable shorter chains of phenolic molecules. The Original also helps digest complex carbohydrates into short chain fatty acids, important for gut health.*\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eMicrobiome and healthy diversity\u003c\/i\u003e: The Original has team playing organisms that help to build healthier communities in the gut.\u003c\/p\u003e","brand":"BioImmersion Inc.","offers":[{"title":"Default Title","offer_id":43712314540076,"sku":"TF013","price":47.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0576\/4779\/2172\/files\/Original-Synbiotic-4.6---Front.jpg?v=1723214776","url":"https:\/\/scoutside-sandbox.myshopify.com\/products\/original-synbiotic-formula","provider":"Scoutside Sandbox","version":"1.0","type":"link"}